T-Cell Receptor Gene Structures of HLA-A26-restricted Cytotoxic T Lymphocyte Lines against Human Autologous Pancreatic Adenocarcinoma
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Isolation of human lymphocyte antigens class I-restricted cytotoxic T lymphocytes against autologous myeloma cells.
Peripheral blood T cells from a patient with multiple myeloma in complete remission were selected in vitro against an autologous myeloma cell line (SBN-1), using a protocol designed for the selection of relatively rare precursor cytotoxic T cells (pCTL). Delayed addition (2 weeks) of interleukin 2 induced T-cell proliferation, and a bulk culture (T-cell line) was obtained 2 days later. This T-c...
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Many human leukocyte antigen (HLA)-class I (mainly A*0201)-restricted peptide-specific cytotoxic T cells (CTLs) have been derived from peripheral blood lymphocytes (PBLs) of melanoma patients. However, few studies regarding HLA-A*2402-restricted melanoma-associated peptides have been performed, because HLA-A24 is not a common allele in Caucasians. In this study, we investigated the specific CTL...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1995
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1995.tb02454.x